4-Methyldiphenhydramine

p-Methyldiphenhydramine
Identifiers
IUPAC name
  • N,N-Dimethyl-2-[(4-methylphenyl)(phenyl)methoxy]ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.039.375
Chemical and physical data
FormulaC18H23NO
Molar mass269.388 g·mol−1
3D model (JSmol)
SMILES
  • O(CCN(C)C)C(c1ccccc1)c2ccc(cc2)C
InChI
  • InChI=1S/C18H23NO/c1-15-9-11-17(12-10-15)18(20-14-13-19(2)3)16-7-5-4-6-8-16/h4-12,18H,13-14H2,1-3H3 checkY
  • Key:PJUYQWIDNIAHIZ-UHFFFAOYSA-N checkY
  (verify)

4-Methyldiphenhydramine is an antihistamine and anticholinergic.[1][2]

It is structurally analogous to diphenhydramine.

References

  1. ↑ Rekker RF, Timmerman H, Harms AF, Nauta WT (May 1971). "The antihistaminic and anticholinergic activities of optically active diphenhydramine derivatives. The concept of complementarity". Arzneimittel-Forschung. 21 (5): 688–91. PMID 4398311.
  2. ↑ Rekker RF, Timmerman H, Nauta WT (1972). "Changes in antihistaminic and anticholinergic activities of diphenhydramine derivatives on quaternization and the role of an asymmetric centre". Chimica Therapeutica. 7 (4): 279–282.


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