Putting images side by side is normally done using minipage, and on top of each other can be done by just seeing to that they occupy enough space to end up on different lines. It is not clear from the question if there should be individual captions or not. This solution should work in most cases. To get the spacing right for your pictures try changing the scaling factors.
\documentclass{article}
\usepackage{graphicx}
\begin{document}
\begin{figure}[htb]
\begin{minipage}[b]{0.7\linewidth}
\centering
\includegraphics[width=0.89\linewidth]{example-image-a}
\caption{Picture A}
\end{minipage}%
\begin{minipage}[b]{0.3\linewidth}
\centering
\includegraphics[width=0.8\linewidth]{example-image-b}
\caption{Picture B}
\vspace*{\baselineskip} %% Space between small pictures
\includegraphics[width=0.8\linewidth]{example-image-c}
\caption{Picture C}
\end{minipage}
\end{figure}
\begin{figure}[htb]
\begin{minipage}[b]{0.7\linewidth}
\centering
\includegraphics[width=0.8\linewidth]{example-image-a}
\end{minipage}%
\begin{minipage}[b]{0.3\linewidth}
\centering
\includegraphics[width=0.85\linewidth]{example-image-b}
\hbox to \linewidth{} %% Space between small pictures
\includegraphics[width=0.85\linewidth]{example-image-c}
\end{minipage}
\caption{One caption for all pictures.}
\end{figure}
\end{document}

Edit
To have one common caption for all images and also let each one have its own caption the packets subfloats, subfig or subcaption can be used. Below is an example using subcaption where the minipage used earlier is replaced buy the subfigure environment.
\documentclass{article}
\usepackage{graphicx}
\usepackage{subcaption}
\begin{document}
\begin{figure}[htb]
\begin{subfigure}[b]{0.7\linewidth}
\centering
\includegraphics[width=0.89\linewidth]{example-image-a}
\caption{Picture A}
\end{subfigure}%
\begin{subfigure}[b]{0.3\linewidth}
\centering
\includegraphics[width=0.84\linewidth]{example-image-b}
\caption{Picture B}
\vspace*{\baselineskip} %% Space between small pictures
\includegraphics[width=0.84\linewidth]{example-image-c}
\caption{Picture C}
\end{subfigure}
\caption{Common caption for all pictures}
\end{figure}
\end{document}
