Notepad++ is a text editor. What this amounts to is nothing more than fancy syntax highlighting and some code completion. Text editors don't give you the full range of robust tools and options, as their target is something between a full-blown IDE but without the bloat. These generally presume that you can debug your code using third party applications.
Netbeans is an IDE. An IDE's only purpose is to enable rapid development of software, so it adds in extra features, such as good code completion, refactoring tools, debugging tools, and certain IDEs can even integrate with a version control system (VCS).
Ultimately, the answer is "no", you can't really use Notepad++ like you would Netbeans. But if Notepad++ has the plugin support for it, it's certainly possible. It'd just be less painful to download Netbeans and use that, instead.
Alternatively, you can look into other non-free Python editors. IntelliJ and PyCharm are two of the very best out there.