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If for example my Tempest Cleric were to cast Fog Cloud into a room of enemies would they roll at a disadvantage when my Wizard companion hurls a Shatter into that room?

SevenSidedDie
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Thick fog, as produced by fog cloud, causes those within it to “effectively suffer[] from the blinded condition” (PHB, p. 183). The Blinded condition does not affect saving throws, only ability checks (which saving throws are not) and attack rolls they make or made against them (PHB, p. 290).

Hence, no — being in a fog cloud won't impose disadvantage on anyone's saving throws against shatter.

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