You can use +,-,*,/,^,! and sqrt operations (no concatenation) and all numbers must be used once and only once. for example, 75 can be made by $3×(4!+2-1)$ and $81=(2-1)×3^4$
I've been trying to reach 100 and this appears to be the first impossible number. Similar using 1 to 5, 202 appears to be the first impossible number.