Vascular endothelial zinc finger 1

VEZF1
Identifiers
Aliases	VEZF1, DB1, ZNF161, vascular endothelial zinc finger 1
External IDs	OMIM: 606747; MGI: 1313291; HomoloGene: 5175; GeneCards: VEZF1; OMA:VEZF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	57,988,259 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; internal globus pallidus; ; ventricular zone; ; bronchial epithelial cell; ; ganglionic eminence; ; germinal epithelium; ; caput epididymis; ; tail of epididymis; ; Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; nucleic acid binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; nucleus;
Biological process	regulation of transcription by RNA polymerase II; cellular defense response; regulation of transcription, DNA-templated; transcription by RNA polymerase II; endothelial cell development; angiogenesis; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; positive regulation of endothelial cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	7716
	22344
	ENSG00000136451
	ENSMUSG00000018377
	Q14119
	n/a
	NM_007146; NM_001330393
	NM_016686
	NP_001317322; NP_009077
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Vascular endothelial zinc finger 1 is a protein that in humans is encoded by the VEZF1 gene. ^[4]

Function

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000136451 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Vascular endothelial zinc finger 1". Retrieved 2016-06-01.

Gowher H, Brick K, Camerini-Otero RD, Felsenfeld G (2012). "Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 109 (7): 2370–5. Bibcode:2012PNAS..109.2370G. doi:10.1073/pnas.1121538109. PMC 3289347. PMID 22308494.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000136451 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: Vascular endothelial zinc finger 1". Retrieved 2016-06-01.

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Vascular endothelial zinc finger 1

Function

References

Further reading