SIK1

SIK1
Identifiers
Aliases	SIK1, MSK, SIK, SNF1LK, EIEE30, salt inducible kinase 1, SIK-1, SIK1B, DEE30
External IDs	OMIM: 605705; MGI: 104754; HomoloGene: 136094; GeneCards: SIK1; OMA:SIK1 - orthologs
Gene location (Human)
Chr.	Chromosome 21 (human)
End	43,427,131 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	32,074,778 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; skin of abdomen; ; skin of leg; ; gallbladder; ; bone marrow cells; ; left ovary; ; left uterine tube; ; vagina; ; right ovary; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; decidua; ; yolk sac; ; lip; ; muscle of thigh; ; genital tubercle; ; proximal tubule; ; tail of embryo; ; esophagus; ; endocardial cushion;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; cAMP response element binding protein binding; 14-3-3 protein binding; metal ion binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; protein kinase binding; magnesium ion binding;
Cellular component	cytoplasm; nucleus; nucleotide-activated protein kinase complex;
Biological process	regulation of myotube differentiation; cell differentiation; intracellular signal transduction; phosphorylation; regulation of sodium ion transport; rhythmic process; cardiac muscle cell differentiation; negative regulation of triglyceride biosynthetic process; negative regulation of CREB transcription factor activity; multicellular organism development; protein phosphorylation; negative regulation of gluconeogenesis; regulation of mitotic cell cycle; regulation of cell differentiation; protein autophosphorylation; cell cycle; positive regulation of anoikis; entrainment of circadian clock by photoperiod; cellular response to hormone stimulus; negative regulation of TOR signaling; cellular response to glucose starvation;
	Sources:Amigo / QuickGO
Orthologs
	150094
	17691
	ENSG00000142178
	ENSMUSG00000024042
	P57059
	Q60670
	NM_173354
	NM_010831
	NP_001307572
	NP_034961
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000142178 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024042 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ruiz JC, Conlon FL, Robertson EJ (Apr 1995). "Identification of novel protein kinases expressed in the myocardium of the developing mouse heart". Mech Dev. 48 (3): 153–64. doi:10.1016/0925-4773(94)90056-6. PMID 7893599. S2CID 24459160.
↑ "Entrez Gene: SNF1LK SNF1-like kinase".

Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". FEBS J. 274 (13): 3202–9. doi:10.1111/j.1742-4658.2007.05889.x. PMID 17565599. S2CID 30323449.
Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". J. Cell Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228. S2CID 17404931.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID 9920726.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000142178 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024042 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7893599-5] Ruiz JC, Conlon FL, Robertson EJ (Apr 1995). "Identification of novel protein kinases expressed in the myocardium of the developing mouse heart". Mech Dev. 48 (3): 153–64. doi:10.1016/0925-4773(94)90056-6. PMID 7893599. S2CID 24459160.

[entrez-6] "Entrez Gene: SNF1LK SNF1-like kinase".

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[2]

[3]

[4]

[5]

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Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

SIK1

See also

References

Further reading