SFMBT1
Scm-like with four mbt domains 1 is a protein that in humans is encoded by the SFMBT1 gene. [1]
Function
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]. It encodes a transcriptional repressor protein.[2][3] The SFMBT1 protein's interaction with cancers is unclear, but elevated levels have been recorded in some renal cancers.[4]
References
- ↑ "Entrez Gene: Scm-like with four mbt domains 1". Retrieved 2013-11-22.
- ↑ Wu, Shumin; Trievel, Raymond C.; Rice, Judd C. (2007-07-10). "Human SFMBT is a transcriptional repressor protein that selectively binds the N-terminal tail of histone H3". FEBS Letters. 581 (17): 3289–3296. Bibcode:2007FEBSL.581.3289W. doi:10.1016/j.febslet.2007.06.025. ISSN 0014-5793. PMC 2045647. PMID 17599839.
- ↑ "SCM-like protein with 4 MBT domains 1; SFMBT1". Online Mendelian Inheritance in Man (OMIM). 2024-12-10. Retrieved 2024-12-10.
- ↑ X, Liu; JM, Simon; H, Xie; L, Hu; J, Wang; G, Zurlo; C, Fan; TS, Ptacek; L, Herring; X, Tan; M, Li; AS, Baldwin; WY, Kim; T, Wu; MW, Kirschner; K, Gong; Q, Zhang (2020). "Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss". Molecular Cell. 77 (6): 1294–1306.e5. doi:10.1016/j.molcel.2020.01.009. ISSN 1097-4164. PMC 7093231. PMID 32023483.
Further reading
- Zhang, J.; Bonasio, R.; Strino, F.; Kluger, Y.; Holloway, J. K.; Modzelewski, A. J.; Cohen, P. E.; Reinberg, D. (2013). "SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors". Genes & Development. 27 (7): 749–766. doi:10.1101/gad.210963.112. PMC 3639416. PMID 23592795.
- Köttgen, A.; Albrecht, E.; Teumer, A.; Vitart, V.; Krumsiek, J.; Hundertmark, C.; Pistis, G.; Ruggiero, D.; O'Seaghdha, C. M.; Haller, T.; Yang, Q.; Tanaka, T.; Johnson, A. D.; Kutalik, Z. N.; Smith, A. V.; Shi, J.; Struchalin, M.; Middelberg, R. P. S.; Brown, M. J.; Gaffo, A. L.; Pirastu, N.; Li, G.; Hayward, C.; Zemunik, T.; Huffman, J.; Yengo, L.; Zhao, J. H.; Demirkan, A.; Feitosa, M. F.; et al. (2012). "Genome-wide association analyses identify 18 new loci associated with serum urate concentrations". Nature Genetics. 45 (2): 145–154. doi:10.1038/ng.2500. PMC 3663712. PMID 23263486.
- Kato, T.; Sato, H.; Emi, M.; Seino, T.; Arawaka, S.; Iseki, C.; Takahashi, Y.; Wada, M.; Kawanami, T. (2011). "Segmental copy number loss of SFMBT1 gene in elderly individuals with ventriculomegaly: A community-based study". Internal Medicine (Tokyo, Japan). 50 (4): 297–303. doi:10.2169/internalmedicine.50.4505. PMID 21325761.
- Lin, S.; Shen, H.; Li, J. -L.; Tang, S.; Gu, Y.; Chen, Z.; Hu, C.; Rice, J. C.; Lu, J.; Wu, L. (2013). "Proteomic and Functional Analyses Reveal the Role of Chromatin Reader SFMBT1 in Regulating Epigenetic Silencing and the Myogenic Gene Program". Journal of Biological Chemistry. 288 (9): 6238–6247. doi:10.1074/jbc.M112.429605. PMC 3585059. PMID 23349461.
- Yang, H. C.; Liang, Y. J.; Chen, J. W.; Chiang, K. M.; Chung, C. M.; Ho, H. Y.; Ting, C. T.; Lin, T. H.; Sheu, S. H.; Tsai, W. C.; Chen, J. H.; Leu, H. B.; Yin, W. H.; Chiu, T. Y.; Chern, C. I.; Lin, S. J.; Tomlinson, B.; Guo, Y.; Sham, P. C.; Cherny, S. S.; Lam, T. H.; Thomas, G. N.; Pan, W. H. (2012). Mariño-Ramírez, Leonardo (ed.). "Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as Hypertension Susceptibility Genes in Han Chinese with a Genome-Wide Gene-Based Association Study". PLOS ONE. 7 (3): e32907. Bibcode:2012PLoSO...732907Y. doi:10.1371/journal.pone.0032907. PMC 3315540. PMID 22479346.
- Morel, S.; Lévy, F.; Burlet-Schiltz, O.; Brasseur, F.; Probst-Kepper, M.; Peitrequin, A. L.; Monsarrat, B.; Van Velthoven, R.; Cerottini, J. C.; Boon, T.; Gairin, J. E.; Van Den Eynde, B. J. (2000). "Processing of some antigens by the standard proteasome but not by the immunoproteasome results in poor presentation by dendritic cells". Immunity. 12 (1): 107–117. doi:10.1016/S1074-7613(00)80163-6. PMID 10661410.
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