Olfactomedin 4
| OLFM4 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | OLFM4, GC1, GW112, OLM4, OlfD, UNQ362, bA209J19.1, hGC-1, hOLfD, olfactomedin 4 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614061; MGI: 2685142; HomoloGene: 4684; GeneCards: OLFM4; OMA:OLFM4 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactomedin 4 is a protein that in humans is encoded by the OLFM4 gene. [5]
Function
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflamed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000102837 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022026 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Olfactomedin 4". Retrieved 2018-01-19.
Further reading
- Liu W, Chen L, Zhu J, Rodgers GP (2006). "The glycoprotein hGC-1 binds to cadherin and lectins". Exp. Cell Res. 312 (10): 1785–97. doi:10.1016/j.yexcr.2006.02.011. PMID 16566923.
- Liu W, Zhu J, Cao L, Rodgers GP (2007). "Expression of hGC-1 is correlated with differentiation of gastric carcinoma". Histopathology. 51 (2): 157–65. doi:10.1111/j.1365-2559.2007.02763.x. PMID 17650212. S2CID 27058889.
- Liu W, Liu Y, Zhu J, Wright E, Ding I, Rodgers GP (2008). "Reduced hGC-1 protein expression is associated with malignant progression of colon carcinoma". Clin. Cancer Res. 14 (4): 1041–9. doi:10.1158/1078-0432.CCR-07-4125. PMID 18281536.
- Conrotto P, Roesli C, Rybak J, Kischel P, Waltregny D, Neri D, Castronovo V (2008). "Identification of new accessible tumor antigens in human colon cancer by ex vivo protein biotinylation and comparative mass spectrometry analysis". Int. J. Cancer. 123 (12): 2856–64. doi:10.1002/ijc.23861. PMID 18798264. S2CID 19686678.
- van der Flier LG, Haegebarth A, Stange DE, van de Wetering M, Clevers H (2009). "OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells". Gastroenterology. 137 (1): 15–7. doi:10.1053/j.gastro.2009.05.035. PMID 19450592.
- Oue N, Sentani K, Noguchi T, Ohara S, Sakamoto N, Hayashi T, Anami K, Motoshita J, Ito M, Tanaka S, Yoshida K, Yasui W (2009). "Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients". Int. J. Cancer. 125 (10): 2383–92. doi:10.1002/ijc.24624. PMID 19670418.
- Liu W, Lee HW, Liu Y, Wang R, Rodgers GP (2010). "Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis". Blood. 116 (23): 4938–47. doi:10.1182/blood-2009-10-246439. PMC 3012588. PMID 20724538.
- Grover PK, Hardingham JE, Cummins AG (2010). "Stem cell marker olfactomedin 4: critical appraisal of its characteristics and role in tumorigenesis". Cancer Metastasis Rev. 29 (4): 761–75. doi:10.1007/s10555-010-9262-z. PMID 20878207. S2CID 35708557.
- Dassen H, Punyadeera C, Delvoux B, Schulkens I, Marchetti C, Kamps R, Klomp J, Dijcks F, de Goeij A, D'Hooghe T, Kyama C, Ederveen A, Dunselman G, Groothuis P, Romano A (2010). "Olfactomedin-4 regulation by estrogen in the human endometrium requires epidermal growth factor signaling". Am. J. Pathol. 177 (5): 2495–508. doi:10.2353/ajpath.2010.100026. PMC 2966806. PMID 21048224.
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