OR1A1

OR1A1
Identifiers
AliasesOR1A1, OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDsOMIM: 618046; MGI: 1333770; HomoloGene: 8219; GeneCards: OR1A1; OMA:OR1A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8383

258706

Ensembl

ENSG00000172146

ENSMUSG00000070377

UniProt

Q9P1Q5

n/a

RefSeq (mRNA)

NM_014565
NM_001386104

NM_146711

RefSeq (protein)

NP_055380

n/a

Location (UCSC)Chr 17: 3.21 – 3.22 MbChr 11: 74.1 – 74.1 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.[5][6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.[6]

Ligands

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.[7][8] Examples of known ligands, most of which have citrus or fruity smells:[9][10]

  • (S)-(−)-citronellal
  • Helional
  • Heptanal
  • Octanal
  • Nonanal (weaker than heptanal/octanal[9])
  • Hydroxycitronellal
  • Citral
  • Citronellol (both enantiomers, weaker than citronellal[9])
  • Dihydrojasmone[7]
  • Thiols[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172146 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070377 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
  6. 1 2 "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".
  7. 1 2 Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
  8. 1 2 Block E, Batista VS, Matsunami H, Zhuang H, Ahmed L (May 2017). "The role of metals in mammalian olfaction of low molecular weight organosulfur compounds". Natural Product Reports. 34 (5): 529–557. doi:10.1039/c7np00016b. PMC 5542778. PMID 28471462.
  9. 1 2 3 Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.
  10. ↑ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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