FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide is gamma chain of high affinity IgE receptor. This protein is encoded by the FCER1G gene in humans.[5]
Function
The high affinity IgE receptor, FcεRI, is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008].
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000158869 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058715 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Entrez Gene: Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide".
Further reading
- Tsuji M, Ezumi Y, Arai M, Takayama H (September 1997). "A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets". The Journal of Biological Chemistry. 272 (38): 23528–31. doi:10.1074/jbc.272.38.23528. PMID 9295288.
- Kihara H, Siraganian RP (September 1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor". The Journal of Biological Chemistry. 269 (35): 22427–32. doi:10.1016/S0021-9258(17)31807-0. PMID 8071371.
- Huang L, Chen S, Zha X, Yang L, Li B, Yu Z, Wang L, Li Y (March 2012). "Expression feature of CD3, FcεRIγ, and Zap-70 in patients with chronic lymphocytic leukemia". Hematology. 17 (2): 71–5. doi:10.1179/102453312X13221316477895. PMID 22664044. S2CID 24701040.
- Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim S, Gho YS, Cho SH, Min KU, Kim YY (April 2007). "Association and functional relevance of E237G, a polymorphism of the high-affinity immunoglobulin E-receptor beta chain gene, to airway hyper-responsiveness". Clinical and Experimental Allergy. 37 (4): 592–8. doi:10.1111/j.1365-2222.2007.02680.x. PMID 17430357. S2CID 25869901.
- Zha X, Yan X, Shen Q, Zhang Y, Wu X, Chen S, Li B, Yang L, Geng S, Weng J, Du X, Li Y (December 2012). "Alternative expression of TCRζ related genes in patients with chronic myeloid leukemia". Journal of Hematology & Oncology. 5: 74. doi:10.1186/1756-8722-5-74. PMC 3544630. PMID 23228155.
- Takahashi K, Hayashi N, Shimokawa T, Umehara N, Kaminogawa S, Ra C (May 2008). "Cooperative regulation of Fc receptor gamma-chain gene expression by multiple transcription factors, including Sp1, GABP, and Elf-1". The Journal of Biological Chemistry. 283 (22): 15134–41. doi:10.1074/jbc.M800498200. PMC 3258888. PMID 18378679.
- Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ (July 2012). "CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl". Journal of Immunology. 189 (2): 786–92. doi:10.4049/jimmunol.1200887. PMC 3665352. PMID 22706086.
- Gross BS, Melford SK, Watson SP (August 1999). "Evidence that phospholipase C-gamma2 interacts with SLP-76, Syk, Lyn, LAT and the Fc receptor gamma-chain after stimulation of the collagen receptor glycoprotein VI in human platelets". European Journal of Biochemistry. 263 (3): 612–23. doi:10.1046/j.1432-1327.1999.00560.x. PMID 10469124.
- Kumar P, Singh B, Lal R, Rembhotkar GW, Singh AB (2009). "Association between reduced levels of total serum IgE and FcepsilonRI expression in non-releaser basophils". Immunobiology. 214 (5): 377–83. doi:10.1016/j.imbio.2008.09.008. PMID 19362683.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.