CCNB1IP1
| CCNB1IP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CCNB1IP1, C14orf18, HEI10, cyclin B1 interacting protein 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 608249; MGI: 2685134; HomoloGene: 18819; GeneCards: CCNB1IP1; OMA:CCNB1IP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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E3 ubiquitin-protein ligase CCNB1IP1 is an enzyme that in humans is encoded by the CCNB1IP1 gene.[5][6]
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM][6] It is considered a housekeeping gene.
During meiosis, crossing over between homologous chromosomes (homologs) facilitates accurate chromosome segregation.[7] In mammals, the ring-domain protein CCNB1IP1, also known as HEI10, promotes crossing over between each pair of homologs during meiosis.[7] Studies in the mouse showed that this pro-crossover ring-domain protein facilitates the homologous recombination and DNA repair processes that produce crossovers.[7]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000100814 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071470 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Toby GG, Gherraby W, Coleman TR, Golemis EA (Mar 2003). "A Novel RING Finger Protein, Human Enhancer of Invasion 10, Alters Mitotic Progression through Regulation of Cyclin B Levels". Mol Cell Biol. 23 (6): 2109–2122. doi:10.1128/MCB.23.6.2109-2122.2003. PMC 149478. PMID 12612082.
- 1 2 "Entrez Gene: CCNB1IP1 cyclin B1 interacting protein 1".
- 1 2 3 Ito M, Yun Y, Kulkarni DS, Lee S, Sandhu S, Nuñez B, Hu L, Lee K, Lim N, Hirota RM, Prendergast R, Huang C, Huang I, Hunter N (January 2025). "Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis". Proc Natl Acad Sci U S A. 122 (2): e2412961121. doi:10.1073/pnas.2412961121. PMC 11745341. PMID 39761402.
External links
- Human CCNB1IP1 genome location and CCNB1IP1 gene details page in the UCSC Genome Browser.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–828. doi:10.1101/gr.6.9.807. PMID 8889549.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
- Grönholm M, Muranen T, Toby GG, et al. (2006). "A functional association between merlin and HEI10, a cell cycle regulator". Oncogene. 25 (32): 4389–4398. doi:10.1038/sj.onc.1209475. PMID 16532029.
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