Pancreatic polypeptide receptor 1

NPY4R
Identifiers
Aliases	NPY4R, NPY4-R, PP1, PPYR1, Y4, Pancreatic polypeptide receptor 1, neuropeptide Y receptor Y4
External IDs	OMIM: 601790; MGI: 105374; HomoloGene: 116086; GeneCards: NPY4R; OMA:NPY4R - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	46,465,958 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	33,874,446 bp
RNA expression pattern
	Top expressed in
	rectum; ; transverse colon; ; muscle layer of sigmoid colon; ; duodenum; ; mucosa of transverse colon; ; smooth muscle tissue; ; skin of abdomen; ; skin of leg; ; appendix; ; stomach;
	Top expressed in
	embryo; ; lip; ; urinary bladder; ; digastric muscle; ; stomach; ; duodenum; ; lumbar spinal ganglion; ; jejunum; ; ileum; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	neuropeptide Y receptor activity; G protein-coupled receptor activity; signal transducer activity; pancreatic polypeptide receptor activity; peptide hormone binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	signal transduction; neuropeptide signaling pathway; chemical synaptic transmission; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5540
	19065
	ENSG00000204174
	ENSMUSG00000048337
	P0DQD5; P50391
	Q61041
	NM_001278794; NM_005972
	NM_008919
	NP_001265724; NP_001265723; NP_005963; NP_001265724
	NP_032945
	Wikidata
View/Edit Human	View/Edit Mouse

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.^[5]^[6]^[7]

Selective Ligands

Agonists

Pancreatic polypeptide
Neuropeptide Y (endogenous agonist, non subtype selective)
Peptide YY
GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Antagonists

UR-AK49^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204174 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048337 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (December 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–290. doi:10.1006/geno.1997.5024. PMID 9417917.
↑ "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
↑ Al-hussaniy HA, AL-Biati HA (2022-12-02). "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis: Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio". Medical and Pharmaceutical Journal. 1 (2). doi:10.55940/medphar20227. ISSN 2957-6067.
↑ Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–233. doi:10.1080/10799890701505206. PMID 17885919. S2CID 26579625.

External links

"Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Keire DA, Bowers CW, Solomon TE, Reeve JR (February 2002). "Structure and receptor binding of PYY analogs". Peptides. 23 (2): 305–321. doi:10.1016/S0196-9781(01)00602-7. PMID 11825645. S2CID 7082920.
Balasubramaniam A (April 2002). "Clinical potentials of neuropeptide Y family of hormones". American Journal of Surgery. 183 (4): 430–434. doi:10.1016/S0002-9610(02)00803-6. PMID 11975932.
Parker E, Van Heek M, Stamford A (April 2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology. 440 (2–3): 173–187. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534.
Benaim G, Villalobo A (August 2002). "Phosphorylation of calmodulin. Functional implications". European Journal of Biochemistry. 269 (15): 3619–3631. doi:10.1046/j.1432-1033.2002.03038.x. hdl:10261/79981. PMID 12153558.
Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, et al. (December 1995). "Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY". The Journal of Biological Chemistry. 270 (49): 29123–29128. doi:10.1074/jbc.270.49.29123. PMID 7493937.
Bard JA, Walker MW, Branchek TA, Weinshank RL (November 1995). "Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY". The Journal of Biological Chemistry. 270 (45): 26762–26765. doi:10.1074/jbc.270.45.26762. PMID 7592911.
Yan H, Yang J, Marasco J, Yamaguchi K, Brenner S, Collins F, Karbon W (May 1996). "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 4661–4665. Bibcode:1996PNAS...93.4661Y. doi:10.1073/pnas.93.10.4661. PMC 39335. PMID 8643460.
Kawabe T, Muslin AJ, Korsmeyer SJ (January 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–458. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
Darby K, Eyre HJ, Lapsys N, Copeland NG, Gilbert DJ, Couzens M, et al. (December 1997). "Assignment of the Y4 receptor gene (PPYR1) to human chromosome 10q11.2 and mouse chromosome 14". Genomics. 46 (3): 513–515. doi:10.1006/geno.1997.5071. PMID 9441761.
Hsieh-Wilson LC, Allen PB, Watanabe T, Nairn AC, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–4373. doi:10.1021/bi982900m. PMID 10194355.
Smith FD, Oxford GS, Milgram SL (July 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". The Journal of Biological Chemistry. 274 (28): 19894–19900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, Marks AR (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. 101 (4): 365–376. doi:10.1016/S0092-8674(00)80847-8. PMID 10830164. S2CID 6496567.
Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Molecular and Cellular Biology. 21 (20): 6841–6850. doi:10.1128/MCB.21.20.6841-6850.2001. PMC 99861. PMID 11564868.
Cavadas C, Silva AP, Mosimann F, Cotrim MD, Ribeiro CA, Brunner HR, Grouzmann E (December 2001). "NPY regulates catecholamine secretion from human adrenal chromaffin cells". The Journal of Clinical Endocrinology and Metabolism. 86 (12): 5956–5963. doi:10.1210/jcem.86.12.8091. hdl:10316/12627. PMID 11739470.
Cox HM, Tough IR (March 2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology. 135 (6): 1505–1512. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964.
Wu DY, Tkachuck DC, Roberson RS, Schubach WH (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". The Journal of Biological Chemistry. 277 (31): 27706–27715. doi:10.1074/jbc.M200955200. PMID 12016208.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000204174 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048337 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9417917-5] Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (December 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–290. doi:10.1006/geno.1997.5024. PMID 9417917.

[entrez-6] "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".

[7] Al-hussaniy HA, AL-Biati HA (2022-12-02). "The Role of Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio in Obesogenesis: Leptin Hormone, Neuropeptide Y, Ghrelin and Leptin/Ghrelin ratio". Medical and Pharmaceutical Journal. 1 (2). doi:10.55940/medphar20227. ISSN 2957-6067.

[pmid17885919-8] Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–233. doi:10.1080/10799890701505206. PMID 17885919. S2CID 26579625.

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