Butamisole

Butamisole
Identifiers
IUPAC name
  • 2-Methyl-N-[3-(2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl)phenyl]propanamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H19N3OS
Molar mass289.40 g·mol−1
3D model (JSmol)
SMILES
  • CC(C)C(=O)NC1=CC=CC(=C1)C2CN3CCSC3=N2
InChI
  • InChI=1S/C15H19N3OS/c1-10(2)14(19)16-12-5-3-4-11(8-12)13-9-18-6-7-20-15(18)17-13/h3-5,8,10,13H,6-7,9H2,1-2H3,(H,16,19)
  • Key:YWDWYOALXURQPZ-UHFFFAOYSA-N

Butamisole is a pharmaceutical drug used in veterinary medicine.[1] It is an anthelmintic of the imidazothiazole class.[2] In dogs it is used for the treatment of infections with whipworms such as Trichuris vulpis and with hookworm such as Ancylostoma caninum.[3] It acts as a nicotinic acetylcholine receptor agonist that causes sustained muscle contraction in the parasite followed by depolarizing neuromuscular blockade which leads to paralysis.[3]

References

  1. ↑ Alford BT, Wang GT, Garces TR, Dougherty RB, Bradley RE (April 1979). "The efficacy and safety of injectable butamisole in dogs". Veterinary Medicine, Small Animal Clinician. 74 (4): 487–495. PMID 256371.
  2. ↑ Martin RJ (July 1997). "Modes of action of anthelmintic drugs". Veterinary Journal. 154 (1): 11–34. doi:10.1016/S1090-0233(05)80005-X. PMID 9265850.
  3. 1 2 "Butamisole". Inxight Drugs. National Center for Advancing Translational Sciences.
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