Here’s a working example with combofont:
\documentclass[12pt,a5paper]{book}
\usepackage{combofont}
\setupcombofont{schneidler-regular}
{
{file:SchneidlerMed-Med.otf:\combodefaultfeat} at #1pt,
{file:SchneidlerMedSC-Med.otf} at #1pt
}
{
{} ,
0x30-0x39
}
\setupcombofont{schneidler-italic}
{
{file:SchneidlerAma-MedIta.otf:\combodefaultfeat} at #1pt,
{file:SchneidlerAma-MedIta.otf} at #1pt
}
{
{} ,
0x30-0x39
}
\DeclareFontFamily{TU}{schneidler}{}
\DeclareFontShape{TU}{schneidler}{m}{n}{<->combo*schneidler-regular}{}
\DeclareFontShape{TU}{schneidler}{m}{it}{<->combo*schneidler-italic}{}
\renewcommand{\rmdefault}{schneidler}% using \fontfamily{schneidler}\selectfont after \begin{document} would produce lining page numbers in Latin Modern
\linespread{1.103}
\begin{document}
URW’s version of Schneidler Medieval has its lowercase 1234567890 in a
separate, small caps font. This is far less inconvenient on \today\
than it was when I first acquired the type, since we now have
combofont.
\textit{There are no italic small caps, but the result is still
pleasing, because the italic 1234567890 seem to be a hybrid of
uppercase and lowercase figures.}
\end{document}

Because I’m not clever enough to combine my definition of schneidler-regular with an invocation of fontspec to select the italic, I defined schneidler-italic using the same font as both recipient and donor of glyphs. There may well be a better way of proceeding.
Standard ligatures were broken until I added \combodefaultfeat.
A Problem
The above worked because lowercase figures are the default in SchneidlerMedSC-Med.otf. But it’s not clear how to procede when lowercase figures exist in but are not the default of the donor font. Here, for instance, is a deliberately tasteless attempt to combine Punk Nova with Neo Euler:
\documentclass{standalone}
\usepackage{combofont,tikz}
\usetikzlibrary{calendar}
\setupcombofont{punk-regular}
{
{file:punknova-regular.otf:\combodefaultfeat} at #1pt,
{file:euler.otf:+onum} at #1pt
}
{
{} ,
0x30-0x39
}
\DeclareFontFamily{TU}{punk}{}
\DeclareFontShape{TU}{punk}{m}{n}{<->combo*punk-regular}{}
\renewcommand{\rmdefault}{punk}
\begin{document}
\tikz\calendar[dates=2019-02-01 to 2019-02-last,
week list,month label above centered]
if (Sunday) [purple];
\end{document}

I’d have expected +onum to produce Neo Euler’s lowercase figures, but it didn’t. By playing with the luaotfload manual, I found this solution (there may be better ones):
\documentclass{standalone}
\usepackage{combofont,tikz}
\usetikzlibrary{calendar}
\def\feats{mode=base;+kern;+onum}
\setupcombofont{punk-regular}
{
{file:punknova-regular.otf:\combodefaultfeat} at #1pt,
{file:euler.otf:\feats} at #1pt
}
{
{} ,
0x30-0x39
}
\DeclareFontFamily{TU}{punk}{}
\DeclareFontShape{TU}{punk}{m}{n}{<->combo*punk-regular}{}
\renewcommand{\rmdefault}{punk}
\begin{document}
\tikz\calendar[dates=2019-02-01 to 2019-02-last,
week list,month label above centered]
if (Sunday) [purple];
\end{document}
