The term "Vancouver style" or "Vancouver system" seems to be slightly more variable than say, APA style or Chicago style.
Often institutions have their own modifications to the general idea of the style.
(Much like "Harvard style" often just means an author year style.)
According to Wikipedia the home of the "official Vancouver style" is the NLM's Citing Medicine.
From what I can see there, it is essentially a numerical style.
For BibTeX there is vancouver.bst.
For biblatex a quick search on the web only turned up https://github.com/fluffels/biblatex-vancouver, the styles there haven't been updated in years though and the redefinitions of the drivers are indeed quite rough. See also Vancouver citation style in LaTex.
I think your best bet with biblatex is to start from a numeric style and modify it as needed. One prominent feature is the name format which can be reproduced with terseinits=true, firstinits=true and
\DeclareNameAlias{default}{last-first}
\renewcommand*{\revsdnamepunct}{}
As Johannes_B points out in the comments, there is Biblatex style file for New England Journal of Medicine (NEJM) which lead to biblatex-nejm. And indeed what Marco Daniel implements there seems quite close to the Vancouver style requirements linked to above.
The package has been last updated in November 2011 though, and so some of the code might not work that smoothly. From what I could see most of it is still absolutely the right code for the job. The \renewbibmacro*{name:last-first} block, however, can be replaced by the code above.
biblatexout there. There is a BibTeX (.bst) style (here on CTAN). See also Vancouver citation style in LaTex. If you don't have a.bbx/.cbxpair thestyle=vancouveroption cannot help you. – moewe Jan 31 '16 at 14:05biblatexit is a BibTeX style. Note also that what is considered Vancouver style may vary quite a bit from institution to institution. – moewe Jan 31 '16 at 14:24.bststyle the answer is you cannot use it withbiblatex, if you refer to the general concept of the "Vancouver style", then my comment above applies that I don't know about a full implementation of that style forbiblatex. The pre-definednumericstyle might come close to what you want, but you will probably have to apply (quite) some modifications. You could of course stop usingbiblatexand go for good old BibTeX and usevancouver.bst. – moewe Jan 31 '16 at 14:54biblatexover BibTeX, but if you have a.bststyle that suits your needs (and you are mainly writing in English), you can stick to BibTeX. If you want to usebiblatexyou need to accept that currently there is no ready-to-use Vancouver style out there, so you will have to roll your own (starting fromnumericI suppose). – moewe Jan 31 '16 at 15:24