You might like to add \renewbibmacro*{begentry}{\midsentence} to your preamble. This lets biblatex think it should not actually start a new sentence and therefore capitalise the name. You might notice an adverse effect with this method if the first field printed ought to be capitalised by biblatex automatically.
\documentclass{article}
\usepackage[utf8]{inputenc}
\usepackage{filecontents}
\usepackage[style=authoryear]{biblatex}
\renewbibmacro*{begentry}{\midsentence}
\AtBeginDocument{\toggletrue{blx@useprefix}}
\begin{filecontents}{\jobname.bib}
@ARTICLE{vanhelten1891,
AUTHOR = "W. van Helten",
TITLE = "Grammatisches",
JOURNALTITLE = "Beiträge zur Geschichte der deutschen Sprache und Literatur",
YEAR = "1891",
PAGES = "455--488",
VOLUME = "15"}
\end{filecontents}
\addbibresource{\jobname.bib}
\begin{document}
\cite{vanhelten1891}
\printbibliography
\end{document}

There is also a solution to redefine the name macros to not capitalise the name prefix.
It might look more monstrous but is probably the better way to go for stability.
\renewbibmacro*{name:last-first}[4]{%
\ifuseprefix
{\usebibmacro{name:delim}{#3#1}%
\usebibmacro{name:hook}{#3#1}%
\ifblank{#3}{}{%
%\ifcapital% comment out
% {\mkbibnameprefix{\MakeCapital{#3}}\isdot}% and get rid of this
{\mkbibnameprefix{#3}\isdot}%
\ifpunctmark{'}{}{\bibnamedelimc}}%
\mkbibnamelast{#1}\isdot
\ifblank{#4}{}{\bibnamedelimd\mkbibnameaffix{#4}\isdot}%
\ifblank{#2}{}{\revsdnamepunct\bibnamedelimd\mkbibnamefirst{#2}\isdot}}
{\usebibmacro{name:delim}{#1}%
\usebibmacro{name:hook}{#1}%
\mkbibnamelast{#1}\isdot
\ifblank{#4}{}{\bibnamedelimd\mkbibnameaffix{#4}\isdot}%
\ifblank{#2#3}{}{\revsdnamepunct}%
\ifblank{#2}{}{\bibnamedelimd\mkbibnamefirst{#2}\isdot}%
\ifblank{#3}{}{\bibnamedelimd\mkbibnameprefix{#3}\isdot}}}
\renewbibmacro*{name:last}[4]{%
\ifuseprefix
{\usebibmacro{name:delim}{#3#1}%
\usebibmacro{name:hook}{#3#1}%
\ifblank{#3}
{}
{%\ifcapital%<-- commented this out
% {\mkbibnameprefix{\MakeCapital{#3}}\isdot}% and this
{\mkbibnameprefix{#3}\isdot}%
\ifpunctmark{'}{}{\bibnamedelimc}}}
{\usebibmacro{name:delim}{#1}%
\usebibmacro{name:hook}{#1}}%
\mkbibnamelast{#1}\isdot}%
prefix, use\midsentence(I can only state my suggestion in prose ... ). – Sverre Nov 14 '13 at 18:12\midsentenceto the name formatting directive instead of putting it inbegentry. But I refrained from doing so because I thought this to be the cleaner solution, I will investigate though. – moewe Nov 14 '13 at 18:49\midsentencemight have inbegentry. – moewe Nov 14 '13 at 18:57