Questions tagged [survival]

Survival analysis models time to event data, typically time to death or failure time. Censored data are a common problem for survival analyses.

Survival analysis includes an array of non-parametric, semi-parametric, and fully parametric methods for analyzing time to event data. Often, these analyses aim to estimate a survival function, $S(t)$, which describes the proportion of subjects surviving at time $t$. A key feature of survival analysis is the ability to incorporate censored data, in which the event of interest does not occur during the observation period.

The most common form of censoring is "right censoring" where the event doesn't happen by the time the data are collected (e.g. patients who are still alive at the end of the study). Left censoring is when the event happens before the study starts and that is the only information on the time of the event. Interval censoring is when the event occurs at some point in the study, but the point is not precisely known.

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Model suggestion for a Cox regression with time dependent covariates

I´m modeling the effect of pregnancy on the outcome of a disease (dead-alive). Approx 40% of the patients did become pregnant after the time of diagnosis-but at different points in time. So far I´ve done KM plots showing a clear protective effect of…
Misha
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Mean survival time for a log-normal survival function

I've found plenty of formulas showing how to find the mean survival time for an exponential or Weibull distribution, but I'm having considerably less luck for log-normal survival functions. Given the following survival function: $$S(t) = 1 - \phi…
Fomite
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Finding median survival time from survival function

Is the best way to find the median survival time from a survival plot just to draw a horizontal line from $p = 0.5$ to the curve and project down to the x-axis?
Thomas
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Survival analysis where covariates are unavailable for censored data

I am looking at the time required by judges to reach decisions. Each judge assesses a number of applicants and can either approve or not approve the application. The case is finalized when the judge renders his report, which may be some time after…
Placidia
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When (and why) is a conditional logistic regression equivalent to a Cox proportional hazards model?

In the the help for the clogit function in the survival package in R, the details section starts with: It turns out that the logliklihood for a conditional logistic regresson model = loglik from a Cox model with a particular data structure.…
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Appropriate Application of Survival Analysis

I have an experiment that will produce observations of the time until an event occurs. Some basic properties are that We count the number of events that have occurred at some point $t_1,...,t_n$. Event times are interval censored, between…
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How to interpret the output for calculating concordance index (c-index)?

I have posted a "similar" question in another thread. But I think that question is not specific/concrete enough to get the answer I expected. I know that, in survival analysis, the concordance index (c-index) can be used to measure how well a…
Yoanh27
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Proportional hazards assumption

The proportional hazards assumption basically says that the hazard rate does not vary with time. That is, $\text{HR}(t) \equiv \text{HR}$. When can we assume this? What if the hazard ratios at various times are: $2.4, 2.36, 2.27$ and $2.03$? Can we…
Thomas
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Is this a problem for Survival analysis?

I have a dataset of individuals. Each individual has the same start time at which we begin observing them. There is also an end time for all individuals. Some individuals fail before they reach the end time and some individuals never fail and…
user1893354
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How to compare Harrell C-index from different models in survival analysis?

In a dataset with survival event, I calculated Harrell C-index from three different models. Furthermore, I calculated the 95% C.I. for the three different models. So the next question is to compare the discrimination ability of the three…
Yao Zhu
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Estimating Number of DNA Tests to Process Each Day

I'm sending a number of DNA test kits to customers each day. The customers swab their cheeks to gather DNA and send back the kit for processing. I have data about each test kit that has been sent for the past two years. The data includes the date…
cwarden
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Survival Analysis - Delayed Entry?

I'm analysing a data set of loans in order to estimate the prepayment risk. One thing which differs from my experiment setup compared to the usual biological/medical experiments is the "time frame". Medical/biostatistics experiments usually have…
Kosta S.
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Testing survival against frequency of some event

I have the following data for 200 cases/subjects: time to death over a 15 year period, $t$. A datum with a value of 180 months means that the subject did not die over the 15 year period. the frequency of three particular types of event associated…
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How do I compare 2 survival curves?

I am comparing the survival of 2 insect larvae under identical conditions. I have the cumulative survival rate (%) for each day. In my case, I have 100% survival on day 0 (the start of the test) and survival goes down from there. When I plot this…
Stéphane
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Understanding survival at time function

This question is related to a few others (Here,Here) on the topic as I have been searching for information. Hopefully this one is sufficient. 1) I am seeing differences in the relationship between survival at time t, S(t) and the hazard at time t,…
B_Miner
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