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Questions tagged [genetics]

The scientific study of the principles of heredity and the variation of inherited traits among related organisms.

Reference for tag wiki excerpt.

What is Genetics?

by By Dr. Ananya Mandal, MD (published originally in news-medical.net)

"Genetics is the study of heredity. Heredity is a biological process where a parent passes certain genes onto their children or offspring. Every child inherits genes from both of their biological parents and these genes in turn express specific traits. Some of these traits may be physical for example hair and eye color and skin color etc. On the other hand some genes may also carry the risk of certain diseases and disorders that may pass on from parents to their offspring."

A Brief History of Genetic Science and Regulation by gmeducation.org

242 questions
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Why isn't this a problem with heritability studies?

In many studies of heritability, researchers study identical twins raised apart and raised together, and see how much a trait correlates between the two types of twins. Sometimes they use fraternal twins, there are a few variations on the…
Peter Flom
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Statistical significance of genes associated with multiple phenotypes

I have a dataset of gene-phenotype association in this format. I am looking at some combination of phenotypes and genes shared between combination. I would like to use a statistical test to show that the genes shared between two phenotypes are…
Khader Shameer
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Group comparisons among genetically related subjects

Suppose there are three groups of subjects: patients (P), controls (C), and relatives of patients (R). The investigator would like to conduct group comparisons on a behavioral measure. The complexity here is that some of the subjects in group R are…
bluepole
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How to estimate IBD (identity by descent) between two individuals mathematically

I work with data containing SNP genotypes for thousands of individuals. One of the task I had was to perform IBD between the individuals to find out the individual relatedness. I perform the IBD analysis with PLINK…
eXpander
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Defining frequently mutated genes

I have a question regarding defining frequently mutated genes in breast cancer cell lines and primary samples. Basically I'm having difficulty deciding on a threshold for what to call a 'frequently mutated gene.' For example I have a list of 40 cell…
tolo9397
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SNP data, control for sibling effect?

I have some SNP data, and wanted to investigate the association between mother's SNPs and a phenotype in their children. In my model, the child's phenotype is the response variable; mother's SNP is the predictor variable. I also adjust for multiple…
user106506
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