Statistical Analysis Stack Exchange
Statistical Analysis Stack Exchange

Questions tagged [crossover-study]

A crossover study is an experiment in which subjects are given a series of treatments in succession. Ideally, all orderings of treatments are used with equal numbers of subjects. Crossover studies are common in clinical trials. Carryover effects are a special concern with this design.

80 questions
2
votes
1 answer

fixed-sequence, crossover clinical trial in food allergy

I want to conduct a fixed-sequence, crossover clinical trial to compare the effect of stopping allergic food at one time period with that of another time period when they eat the allergic food. When they enter the study, they were eating the…
DrWho
  • 939
2
votes
1 answer

Are cross over clinical trials only suitable for drug treatments?

I wonder please if cross over trials are only applicable to drug treatments ? or maybe also to vaccines ? I can't imagine they are appropriate for surgical interventions or for devices, laser or radiotheray interventions ?? many thanks for views
user3156942
  • 360
1
vote
1 answer

Intention to treat principle in randomized crossover trials

Is it possible to use intention-to-treat principle in randomized studies with crossover design? Was it ever used in such studies?
Viktor
  • 1,007
1
vote
1 answer

Is this a crossover design?

I am working with collaborators who are conducting an education research study to see if there is a difference in learning outcomes between two learning experiences, one with a technology tool (let’s call it Tech) and without (let’s call it…
JackS_Ed
  • 11
1
vote
0 answers

Most appropriate statistical analysis for a 3 treatment, 3 period crossover design

I have a study looking at a particular blood measure after performing 3 activities (sitting (control), walking (intervention 1) and cycling (intervention 2). There will be a minimum wash out period between each trial and it will be randomised (15…
Rosey
  • 11
  • 1
1
vote
0 answers

is there no need for a washout period when using Balaam Design

Balaam design is a crossover design for comparison of regimen A with regimen B in which subjects are randomly allocated to one of four sequences: AA, AB, BA or BB. Sequence AA means that the subjects in this group receive regimen A in period-1…
Martin P. Holt
  • 11
  • 2
0
votes
0 answers

Is it possible to verify that washout period was sufficient? And find out if it can be shortened?

Is it possible to use the data collected during the washout period to verify that the length of the period was sufficient? The carryover effect was not significant (we did not expect a carryover effect) and there were no effects of treatment. I am…
user1762
  • 13
0
votes
1 answer

What data analysis would be best to use for my Masters Dissertation?

I will be conducting an intervention where I will be comparing the effects of Kinesiology Tape and Placebo tape on CECS in motorcycle racers. A reading will be taken pre tape application of both arms, and then readings will be taken again with…
Carrie
  • 1
0
votes
1 answer

crossover design and covariates

I wanted to use a crossover design to compare two treatments (a supplement versus a placebo) on human participants. The advantage of this design is that I don't have to worry about the effects of the confounders, such as age, gender, ethnicity, etc,…
user106506
  • 1