Let $x_1$ and $x_2$ be to columns in your design matrix, and let their covariance be $\operatorname{cov}(x_1, x_2) > 0$.
Mean center the variables so that $z_1 = x_1 - \bar{x_1}$ and $z_2 = x_2 - \bar{x_2}$. The covariance between $z_1$ and $z_2$ is
$$ \operatorname{cov}(z_1, z_2) = \dfrac{1}{N-1}\sum(z_{1,i})(z_{2,i}) = \dfrac{1}{N-1} \sum(x_{1, i} - \bar{x}_1)(x_{2, i} - \bar{x}_2) >0$$
since the sample means of the $z_i$ vectors is 0 by construction. Note that
$$ (N-1)\operatorname{cov}(z_1, z_2) = \sum(z_{1,i})(z_{2,i}) = z_1^Tz_2$$
Hence, if the original data have non-zero covariance (i.e. they are not independent), then the standardized versions are not orthogonal.
Thus, $X_s$ can't be orthogonal unless $X$ is orthogonal.