Yes, it is fair.
In the binomial distribution, the number of events in the heads/success state $n_H$ is not independent of the number of events in the tails/failure state $n_T=N-n_H$. If the events that fall into the tails state are then subsequently subjected to another binomial distribution, say "left" and "right", then the same logic holds, and so on. Using this divide-and-sub-divide method, you can build out the entire multinomial distribution from a set of nested binomials. Perhaps that gives you confidence that treating any one of them as a binomial is OK.
For a multinomial distribution, the joint probability of finding $(n_1,\dots,n_k), $ events in the $k$ bins is
$$
P(n_1,\dots,n_k)=\binom{N}{n_1,\dots,n_k} p_1^{n_i} \dots p_k^{n_k}
$$
The expected number of events in the $i$th bin is $E(n_i)=N p_i$.
The variance of events in the $i$th bin is $var(n_i)=N p_i(1-p_i).$
You'll notice these are exactly the same as the multinomial's binomial counterpart. You may add the constraints $N=\sum n_i$ and $1=\sum p_i$ but it is implied in both binomial and multinomial forms of the problem.
If there are enough events in the bin (generally a minimum of 10 plus another 10 events in all of the other bins combined), you may invoke the normal approximation on the distribution of events and calculate a standard error $se(n_i)= \sqrt{p_i(1-p_i)/N}$ which you can then use to give a normal confidence interval around the mean. Again, just as with the binomial distribution.
If there aren't, then you would have to asses the 95% confidence interval manually, by building the binomial distribution for $n_i=0,1,2\dots$ for each bin.
For the arbitrary binning of continuous variables, nothing changes in the basic multinomial analysis. However, any generalization you wish to make about the $p_i$ would be contingent on the exact set of bins you choose. It is awkward to report the a probability with a full list of bin definitions, so practically speaking, you should have a bin strategy that you can report in only a few words -- "unit intervals centered on the integers," for instance, or "intervals of size 2 centered on the odd integers."
See also
Confidence interval and sample size multinomial probabilities
So part of wanting to compute the SE there is to use prelim. data to help determine what the bin and sampling strategies should be, e.g. how much data we need and how many bins we can afford to have before we lose too much power for any given bin.
– CHP Mar 12 '19 at 05:03