Break it down into steps. You started with:
dict = {'d1':[1,2,{'d2':['this is tricky',{'tough':[1,2,['me']]}]}]}
me = 'me'
tough = [1, 2, [me]]
d2 = ['this is tricky', {'tough': tough}]
d1 = [1, 2, {'d2': d2}]
dict = {'d1': d1}
To access me from me from tough
print(tough[2][0])
To access me from tough from d2
print(d2[1]['tough'])
To access me from d2 from d1
print(d1[2]['d2'])
To access me from d1 from dict
print(dict['d1'])
Chaining them all together
dict['d1'][2]['d2'][1]['tough'][2][0]
Note: avoid naming a variable dict, or for that matter, anything that would shadow any of the Python builtins https://docs.python.org/3/library/functions.html