Python - Pandas DF - Create a DataFrame with unique values based on 2 or more Columns

Question

I have a table with 100 columns and 1M records and loaded into Panda DF.

Example of records:

C1 C2 C3 ...
A  1  2
A  1  2
B  2  2
B  2  2
C  3  2

I want to make unique records based on 2 columns (C1 and C2) - basically I know that if 2 of them are the same - the rest of the columns are the same.

Result would be:

C1 C2 C3 ...
A  1  2
B  2  2
C  3  2

How to achieve this?

Thanks.