Getting this on Windows 10 Pro, Visual Studio 2017. ASP .NET Framework 4.6
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Basil
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Note enabling 32-Bit Applications on IIS did not resolve the issue – Basil Oct 18 '17 at 09:11
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Killed my environment - I am running SharePoint and setting this loses it's mind in IIS (I suspected it would as SP is 64 bit) - the result was interesting - it lost all of the applications. Change back fixed SP but not Visual Studio; in the end it looks like VS 2017 installation broke the environment. – David Sterling May 28 '18 at 10:43
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If this could help --> https://stackoverflow.com/questions/4653236/unable-to-start-debugging-on-the-web-server-could-not-start-asp-net-debugging-v – Gayatri Nov 14 '18 at 19:46
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I had this issue and found that removing a https rewrite rule to force www fixed it for me.
WhiteleyJ
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I have not experienced the issue again for quite a while hence cannot test whether or not this works or not. – Basil Dec 03 '19 at 10:38
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Sometimes I feel like this bug comes up when IIS just needs to recalculate some internal configuration. – WhiteleyJ Jan 17 '20 at 15:09
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Using the task manager to close all Visual Studio processes currently running and restarting visual studio fixed the issue.
Basil
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