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I know there are a lot of variables that affect how quickly this would occur. Any information on the topic would be highly appreciated. For sake of argument, lets say 1 square foot chamber, lets say medium vacuum, and a 1/16 square inch opening. If you could provide me with any formulas or thoughts on the topic that would be very helpful.

Also, how would the speed change with a different gas, say hydrogen? Or even, a liquid such as water?

Thanks

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I depends on the pressure ratio between the chamber and ambient . As long as the ratio is critical, the ambient air will flow through the orifice at the speed of sound (with respect to the state in the chamber). For undercritical pressure ratio the flow can basically be found by the Bernoulli Equation.