No, I don't think we need to know everything to understand reality. What we need is to know enough about everything.
This is what I mean by enough. We understand something by building, in our imagination, a model of it -- and so we understand reality by building a comprehensive model of it. We can think of it as of piecing together its map -- and a map doesn't capture the territory in every detail, only to a certain resolution. It also could be interactive -- if we want to know more about a certain place, we can zoom in to see it in better detail. In general though, a map is useful when it shows everything in good enough resolution.
Going back to our understanding of reality, it should cover all the territory (ideally) and answer our basic questions, like, what is reality anyway? What are its properties -- is it random/chaotic, or ordered/deterministic? What is "deterministic"? Is reality shared, or everyone has their own? How about truth -- what is truth anyway? Also, why we suffer for it? Why we often mistreat each other? How should we treat each other? Can we be happy? What is happiness? Why some people believe in God and some don't? Should you believe in God? What happens after death? What is the meaning of life, what should we live (and, perhaps, suffer) for? What makes us the way we are, what makes us human, what makes us conscious, where our feelings come from, what does it mean to understand, and why it's a struggle?
(this is my stab at it -- at least that's the starting point because that's what we often struggle with when we try to piece together a puzzle)
And, again, once the basics are covered, we can zoom in and get a better understanding of any area of interest -- psychology, physics, poetry, computer science, or why people do "useless" things.