The following may or may not be useful for hub location problems, but is certainly applicable to many problems pertaining to the title "Strategic planning based on average values"
If $X$ is a random variable for which only the mean, $\bar{X}$ is known, sometimes qualitative analysis can be performed to determine the direction of the error between
1) the solution obtained by using the mean of $X$ in lieu of its actual distribution
and
2) the correct solution
In particular, suppose we are interested in $E(f(X))$, the expected value (i.e., mean) of $f(X)$. If the function $f$ is known to be convex, for instance $f(x) = x^2$, or concave, for instance, $f(x) = \sqrt{x}$ or $f(x) = \text{log}(x)$, then Jensen's Inequality can be applied.
If $f(x)$ is convex, Jensen's inequality tells us that $f\bar{X}) \le E(f(X))$ I.e., substitution of $X$ by its mean causes $E(f(X))$ to be underestimated.
If $f(x)$ is concave, Jensen's inequality tells us that $f\bar{X}) \ge E(f(X))$ I.e., substitution of $X$ by its mean causes $E(f(X))$ to be overestimated.
Because it supports such qualitative analysis, Jensen's Inequality is one of the most powerful tools in applied probability, and therefore in Operations Research. Sometimes this qualitative analysis of the error goes in the direction needed to support decisions, even with missing quantitative information.
Note: In the real world, many managers, decision makers, etc, think that the only rigorous analysis is quantitative. In many cases, qualitative analysis is more rigorous and better supports decisions than inadequate quantitative analysis. So sometimes a "sales job" is needed.