Quite famously, Danielewski's House of Leaves is typographically quite.. psychedelic. And deliberately so. It employs a range of fonts, color codes, and not to mention the text is oriented in various ways. In answering another question on this stack exchange, user80 illustrates this very well. It must have been quite a challenge for the editor to work on, let alone the author himself.
Wikipedia mentions "the author "wrote the book in longhand and revised it with a word processor". Somehow that sounds a bit short-sighted or simplistic, as it must be extremely hard to keep track of all the envisioned typographic oddities in handwriting or, even worse, in Microsoft Word.
Is it known how the author typeset this work while writing it? What tools or computer software was employed to make House of Leaves?