Unlike most constellations, Lupus isn't named after a specific character in mythology. It used to be a dog or beast, but eventually it was given the Latin name Lupus. I'm not really sure how gender suffixes work in Latin. It seems like "-us" is associated with male names. But, then again maybe in Latin, Lupus could mean a wolf of either gender, while something like Lupa would only refer to a she-wolf.
So, does the name "Lupus" imply that it is a male wolf? or could it be a female wolf?
(I'm writing a story, and was hoping to reference the constellation Lupus as a she-wolf, but I could change it to "Lupa" or something else if that would fit better. I like the name Lupus because it's the name of an actual constellation, but only if it fits.)