2 Timothy 1:15 - 15 You know that everyone in the Province of Asia has deserted me, including Phygelus and Hermogenes.
There is no reason to read this another was other than everyone means ‘All of Asian’ I haven’t seen any evidence to suggest otherwise.
There is clear evidence that many in Asia that were not happy with Paul as he was preaching something different to what was preached by Jesus and the disciples. So much so, that the Ephesians wrote to the elders for help.
False teachers were expected
Jude 3 Dear friends, although I was very eager to write to you about the salvation we share, I felt compelled to write and urge you to contend for the faith that was once for all entrusted to God’s holy people. 4 For certain individuals whose condemnation was written about long ago have secretly slipped in among you. They are ungodly people, who pervert the grace of our God into a license for immorality and deny Jesus Christ our only Sovereign and Lord.
1 John 4:1 Beloved, believe not every spirit, but try the spirits whether they are of God: because many false prophets are gone out into the world.
Many passages in the bible about false prophets / teachers that will come.
False teachers to Asia
Rev 1:10-11 - 10 On the Lord’s Day I was in the Spirit, and I heard behind me a loud voice like a trumpet, 11 which said: “Write on a scroll what you see and send it to the seven churches: to Ephesus, Smyrna, Pergamum, Thyatira, Sardis, Philadelphia and Laodicea.”
Rev 2:1-3 “To the angel of the church in Ephesus write:
These are the words of him who holds the seven stars in his right hand and walks among the seven golden lampstands. 2 I know your deeds, your hard work and your perseverance. I know that you cannot tolerate wicked people, that you have tested those who claim to be apostles but are not, and have found them false. 3 You have persevered and have endured hardships for my name, and have not grown weary.
The Nicolaitans are mentioned as are some others. But it mentions false prophets – so many were to come.
Paul rejected:
A number of reasons why they thought of Paul as a false apostle;
Paul goes to Ephesus - Acts 19:1 While Apollos was at Corinth, Paul took the road through the interior and arrived at Ephesus. There he found some disciples
Paul calls himself an apostle - Ephesians 1:1 – Salutation - 1 Paul, an apostle of Christ Jesus by the will of God, To the saints who are also faithful in Christ Jesus:
Paul goes against the holy spirit – but still went - Acts 16:6 6 Now when they had gone through Phrygia and the region of Galatia, they were forbidden by the Holy Spirit to preach the word in Asia.
Paul clearly in disagreement with others - Acts 19:8-9 -8 And he entered the synagogue and for three months spoke boldly, arguing and pleading about the kingdom of God; 9 but when some were stubborn and disbelieved, speaking evil of the Way before the congregation, he withdrew from them, taking the disciples with him, and argued daily in the hall of Tyran′nus.
Ask the elders for help against Paul - Acts 21: 27-28 27 When the seven days were almost completed, the Jews from Asia, who had seen him in the temple, stirred up all the crowd, and laid hands on him, 28 crying out, “Men of Israel, help! This is the man who is teaching men everywhere against the people and the law and this place; moreover he also brought Greeks into the temple, and he has defiled this holy place.”
why was he rejected
Clearly Paul was teaching different to Jesus and the other disciples, his teachings in mnay ways are contradictory to the message of Jesus such as the law, a few examples.
Matthew 5:17-19 - 17 Do not think that I have come to abolish the Law or the Prophets; I have not come to abolish them but to fulfill them. 18 For truly, I say to you, until heaven and earth pass away, not an iota, not a dot, will pass from the Law until all is accomplished. 19Therefore whoever relaxes one of the least of these commandments and teaches others to do the same will be called least in the kingdom of heaven, but whoever does them and teaches them will be called great in the kingdom of heaven.
But if you want to enter into life, keep the commandments.”— Mat 19:17
Blessed are those who do His commandments, that they may have the right to the tree of life, and may enter through the gates into the city. — Rev 22:14
Luke 16:17 It is easier for heaven and earth to disappear than for the least stroke of a pen to drop out of the Law.
Here is the patience of the saints; here are those who keep the commandments of God and the faith of Jesus.
— Rev 14:12
Blessed are those who do His commandments, that they may have the right to the tree of life, and may enter through the gates into the city.
— Rev 22:14
Conclusion
Paul is the only one that portrays himself an Apostle, albeit he was not 1 of the twelve. The holy spirit forbid him to go to Asia, Paul preached contrary to Jesus and the disciples, Paul was rejected.
For more on Paul and the Law see: https://hermeneutics.stackexchange.com/a/78251/33268