There is definitely a "not" לֹ֣א in the Hebrew. However, the sense of the sentence in Job 21:16 is still heavily debated as discussed by Ellicott:
(16) Lo, their good (i.e., their prosperity) is not in their own
hand.—And that constitutes the mystery of it, for it is God who gives
it to them; or the words may be a hypothetical answer to his
statement, thus, “Lo, thou repliest, their prosperity is not,” &c.;
and then the words, “the counsel of the wicked is far from me,” are
Job’s indignant repudiation of all knowledge of their reasoning.
Benson is a little more helpful:
Job 21:16. Lo, their good is not in their hand — These words, says
Chappelow, will be more consistent with what goes before, if read with
an interrogation; namely, Lo, is not their good in their hand? that
is, Is not every thing in their power? Do they not enjoy whatever they
desire? To this purpose, he observes, is Sol. Jarchi’s comment. Most
commentators, however, read the words without an interrogation, which
is certainly more agreeable to the Hebrew text. And Poole, with Henry
and several others, consider them as containing an answer to the
foregoing questions, and a confutation of the ungodly opinion and
practice mentioned Job 21:14-15, as if he had said, Wicked men have no
reason to reject God, because of their prosperity, for their wealth is
not in their hand; neither obtained nor kept by their own might, but
only by God’s power and favour. Therefore I am far from approving
their opinion, or following their course. “After the foregoing elegant
description of the prosperity of some wicked men,” says Dr. Dodd, “Job
proceeds, on the other hand, to confess what was likewise apparent in
the ways of Providence, that some of them were as remarkably
distinguished by their wretchedness, being exposed to the most
dreadful evils and calamities. He knew that while he had been
recounting the prosperity of the wicked, he had touched upon a tender
point, to which his adversaries would be apt to give a wrong turn, as
if he had been pleading the cause of iniquity. He therefore guards
against their entertaining any idea of that kind, in this verse, in
which he speaks to this purpose: ‘Do not imagine that because I say
the wicked sometimes prosper, therefore, I believe their prosperity to
be owing to themselves, or in their own hand or power.
Barnes has similar comments:
Lo, their good is not in their hand - Schultens, Rosenmuller, and
Noyes, suppose, I think, correctly, that this is to be understood
ironically, or as referring to what "they" had maintained. "Lo! you
say, that their good is not in their hand! They do not enjoy
prosperity, do they? They are soon overwhelmed with calamity, are
they? How often have I seen it otherwise! How often is it a fact that
they continue to enjoy prosperity, and live and die in peace!" The
common interpretation, which Prof. Lee has adopted, seems to me to be
much less probable. According to that it means that "their prosperity
was not brought about or preserved by their own power. It was by the
power of God, and was under his control. An inscrutable Providence
governs all things." But the true sense is, that Job is replying to
the arguments which they had advanced, and one of those was, that
whatever prosperity they had was not at all secure, but that in a
moment it might be, and often was, wrested from them. Job maintains
the contrary, and affirms that it was a somewhat unusual occurrence
Job 21:17, that the wicked were plunged into sudden calamity. The
phrase "in their hand" means "in their power," or under their control,
and at their disposal.