I'm contemplating the use of U.3 drives in my next desktop PC build, although I have no direct experience with them. (The reason for considering them is largely because I want to be able to run at least some of them in RAID 1 and rotate the drives out periodically; having hot-swap capability would also be nice. Given that M.2 drives are generally right on the motherboard, swapping them out is much less convenient. My current build uses SATA drives but they are now unacceptably slow, relative to the NVMe competition.)
I have found some U.3 enclosures for between 2 and 6 drives (also some U.2, and indeed some say they can do both). These are typically 5.25 inch units with front-opening ports for inserting/removing drives.
The cabling also seems to be straightforward, though I confess I've slightly glossed over that part so far.
However, connecting the drives to the motherboard is less obvious, as I can't find U.3 host adapters. I strongly suspect I'm missing the point somewhere, so this is the main point on which I'd really appreciate some guidance...
I have found multiple different PCIe x16 cards which have 4 SFF-8643 connections, but all of these say they are for U.2 drives. Since I have read that U.3 drives can be used in U.2 backplanes (but not vice-versa), perhaps such cards would actually be an acceptable way to proceed? (Perhaps they are the only way to proceed in fact?!) I've yet to find a single U.3 PCIe card, which baffles me.
I'll note that I've also found adapters which allow an M.2 drive to be converted to U.3 (or U.2) form factor. I would certainly consider using these as part of my setup (it seems to be slightly easier/cheaper to buy M.2 drives than U.3 in the <= 4 TB range), since with a multi-drive enclosure I'd still get the benefits of easily swapping out drives, and I'd just need as many adapters as M.2 drives to keep things really simple. (I don't yet know if this would permit hot-swapping.)
(Regarding the actual enclosures, cables, PCIe cards (etc.) that I've found, I'm not sure it's OK to insert links to commercial offerings here so I'll not do that right now, but happy to add some if this is permitted.)
PS: I have also found PCIe cards onto which a single U.3 drive can be mounted, but I don't see much benefit in these for my application. PPS: this is my first question on this part of the network, and I'm hoping this is the right place to ask it...