Most readers will grammatically parse the sentence as the subject to be singular ("the use of A, B, and C") to match the singular "an uplifting effect".
Semantically, it also makes sense that the subject is singular because "the use of color" doesn't quite match "different perspectives" and "engaging plots". The author must have meant "the use of color, the use of different perspectives, and the use of engaging plots" but drop the repetitive "the use of".
If the author wants to emphasize the unity of subject even further, then as @FumbleFingers noted, he/she could say something like:
As you will see, the use of all three things, color, different perspectives, and engaging plots, combines to have an uplifting effect on your mind, body, and soul.
But composition-wise, using too many noun forms is not advisable. I would rewrite it as follows:
As you will see, using color, different perspectives, and engaging plots can uplift your mind, body, and soul.
If the author DOES want to emphasize that there are 3 subjects, he/she could say something like:
As you will see, the use of color, the variety of different perspectives, and the craft of engaging plots can have uplifting effects on your mind, body, and soul.
or drop the "the use of" altogether and write "effects" instead of "an effect":
As you will see, colors, different perspectives, and engaging plots can have uplifting effects on your mind, body, and soul.