The word order of a question (Who...? What...? When...? Where...? Why...? How...?) shows subject-verb inversion—
Why are finite verb you subject sad?
But a clause with one of those interrogatory words at its head, when it is standing as the answer to a question, will show normal word order:
How is it done? inverted order
-- She will show you {how it is done normal order}.
Such a clause is a proxy for the answer:
Does she want to know {something}?
—Yes, she wants to know {what it is about}.
What is it about?
—Bacteria in zero-gravity conditions is {what it is about}.
{Bacteria in zero-gravity conditions} = {what it is about}.
Only when you are asking the question or quoting the question verbatim do you use subject-verb inversion with these interrogatory words, because then you are asking the question or repeating the question exactly as it was asked, not paraphrasing it:
Does she want to know {something}?
—Yes, I will repeat her question. She asked, "What is it about?"