Complexity theory seems to capture something fundamental about the structure of the universe, in that it formalizes the intuitive notion that some problems are harder than others.
Scott Aaronson predicted, "The NP Hardness Assumption will eventually be seen as analogous to the Second Law of Thermodynamics or impossibility of superluminal signaling."
So-called "hard problems" are the basis of modern cryptography.
Are there any other applications that utilize, depend on, or exemplify the existence of computationally hard problems?