How does Cellminer's "Cross-correlations of transcripts, drugs, and microRNAs" work

Question

I have seen one of Cellminer tools. I am not sure how do they calculate the cross correlation of the genes, what does it actually mean? Based on what databases?

For example if I take their example input (HUGO format):

abcb1
BRCA2
CNBP

I get the following cross correlation matrix (based on what signals).

Identifier      abcb1   BRCA2   CNBP
abcb1           1      -0.142   0.069
BRCA2          -0.142   1       0.176
CNBP           0.069    0.176   1

You're probably best asking the authors – ithinkiam Aug 18 '17 at 09:00 — ithinkiam, Aug 18 '17 at 09:00

score 2 · Accepted Answer · answered Jun 20 '17 at 08:34

In the article describing Cellminer says about the cross-correlations:

... a cross-correlation table of the resultant z-scores can be generated ...

On page 3503

And the z-scores are defined previously as:

The tool output includes relative transcript intensity presented as z-scores...

How does Cellminer's "Cross-correlations of transcripts, drugs, and microRNAs" work

1 Answers1