Ciclooxigenază

prostaglandin-endoperoxide synthase
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Ciclooxigenaza (EC 1.14.99.1, abreviată COX) este o enzimă cu rol în transformarea acidului arahidonic în prostaglandine.[1] Are rol în afecțiuni inflamatorii,[2] coagularea sângelui și în proliferarea celulară.

Note

Liu J; Seibold SA; Rieke CJ; Song I; Cukier RI; Smith WL (iunie 2007). „Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation”. The Journal of Biological Chemistry. 282 (25): 18233–44. doi:10.1074/jbc.M701235200. PMID 17462992.
Litalien C; Beaulieu P (2011). „Chapter 117 – Molecular Mechanisms of Drug Actions: From Receptors to Effectors”. În Fuhrman BP; Zimmerman JJ. Pediatric Critical Care (ed. 4th). Philadelphia, PA: Elsevier Saunders. pp. 1553–1568. doi:10.1016/B978-0-323-07307-3.10117-X. ISBN 978-0-323-07307-3. Arachidonic acid is a component of membrane phospholipids released either in a one-step process, after phospholipase A2 (PLA2) action, or a two-step process, after phospholipase C and DAG lipase actions. Arachidonic acid is then metabolized by cyclooxygenase (COX) and 5-lipoxygenase, resulting in the synthesis of prostaglandins and leukotrienes, respectively. These intracellular messengers play an important role in the regulation of signal transduction implicated in pain and inflammatory responses.

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[1] Liu J; Seibold SA; Rieke CJ; Song I; Cukier RI; Smith WL (iunie 2007). „Prostaglandin endoperoxide H synthases: peroxidase hydroperoxide specificity and cyclooxygenase activation”. The Journal of Biological Chemistry. 282 (25): 18233–44. doi:10.1074/jbc.M701235200. PMID 17462992.

[Litalien_2011-2] Litalien C; Beaulieu P (2011). „Chapter 117 – Molecular Mechanisms of Drug Actions: From Receptors to Effectors”. În Fuhrman BP; Zimmerman JJ. Pediatric Critical Care (ed. 4th). Philadelphia, PA: Elsevier Saunders. pp. 1553–1568. doi:10.1016/B978-0-323-07307-3.10117-X. ISBN 978-0-323-07307-3. Arachidonic acid is a component of membrane phospholipids released either in a one-step process, after phospholipase A2 (PLA2) action, or a two-step process, after phospholipase C and DAG lipase actions. Arachidonic acid is then metabolized by cyclooxygenase (COX) and 5-lipoxygenase, resulting in the synthesis of prostaglandins and leukotrienes, respectively. These intracellular messengers play an important role in the regulation of signal transduction implicated in pain and inflammatory responses.