Membrane steroid receptor
Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids that mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades.[1][2][3][4] mSRs are another means besides classical nuclear steroid hormone receptors (SHRs) for steroids to mediate their biological effects.[1][2][3][4] SHRs can produce slow genomic responses or rapid, non-genomic responses in the case of mSRs.[5]
List of membrane steroid receptors
Known groups of mSRs, by ligand, include:[a]
- Membrane sex steroid receptors
- Membrane corticosteroid receptors
- Membrane glucocorticoid receptors (mGRs) – caveolin-associated nuclear receptors; possible unidentified receptors[6]
- Membrane mineralocorticoid receptors (mMRs) – caveolin-associated NRs; diverse putative receptors[6]
In addition, PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form of Vitamin D.[8]
References
- ↑ Semicolons roughly denote structural groups, e.g. G-protein receptors from ion channels.
- 1 2 Levin ER (June 2014). "Translating extranuclear steroid receptor signaling to clinical medicine". Hormones & Cancer. 5 (3): 140–145. doi:10.1007/s12672-014-0179-9. PMC 4040225. PMID 24752388.
- 1 2 Hammes SR, Levin ER (December 2011). "Minireview: Recent advances in extranuclear steroid receptor actions". Endocrinology. 152 (12): 4489–4495. doi:10.1210/en.2011-1470. PMC 3858720. PMID 22028449.
- 1 2 Sen A, Prizant H, Hammes SR (August 2011). "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology". Steroids. 76 (9): 822–828. doi:10.1016/j.steroids.2011.02.016. PMC 4972037. PMID 21354434.
- 1 2 Watson CS (December 1999). "Signaling themes shared between peptide and steroid hormones at the plasma membrane". Science's STKE. 1999 (12): PE1. doi:10.1126/stke.1999.12.pe1. PMC 1317563. PMID 11865187.
- ↑ Norman AW, Mizwicki MT, Norman DP (January 2004). "Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model". Nature Reviews. Drug Discovery. 3 (1): 27–41. doi:10.1038/nrd1283. PMID 14708019. S2CID 17487277.
- 1 2 3 4 5 6 7 Treviño LS, Gorelick DA (August 2021). "The Interface of Nuclear and Membrane Steroid Signaling". Endocrinology. 162 (8): bqab107. doi:10.1210/endocr/bqab107. PMC 8214340. PMID 34038515.
- ↑ Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, et al. (January 2025). "Identification, structure, and agonist design of an androgen membrane receptor". Cell. doi:10.1016/j.cell.2025.01.006. PMID 39884271.
- ↑ Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, et al. (November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. Bibcode:2016NatSR...637957G. doi:10.1038/srep37957. PMC 5126700. PMID 27897272.
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