Deltex e3 ubiquitin ligase 3

DTX3
Identifiers
AliasesDTX3, RNF154, deltex3, deltex 3, E3 ubiquitin ligase, deltex E3 ubiquitin ligase 3
External IDsOMIM: 613142; MGI: 2135752; HomoloGene: 12754; GeneCards: DTX3; OMA:DTX3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

196403

80904

Ensembl

ENSG00000178498

ENSMUSG00000040415

UniProt

Q8N9I9

Q80V91

RefSeq (mRNA)

NM_001286245
NM_001286246
NM_178502

NM_030714
NM_001368332

RefSeq (protein)

NP_001273174
NP_001273175
NP_848597

NP_109639
NP_001355261

Location (UCSC)Chr 12: 57.6 – 57.61 MbChr 10: 127.19 – 127.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable E3 ubiquitin-protein ligase DTX3 is a protein that in humans is encoded by the DTX3 gene.[5] It is expressed in three isoform variants differing on the N-terminal end: DTX3a, DTX3b, and DTX3c.[6] DTX3a and DTX3b have distinct sets of 7 or 10 N-terminal amino acids, while DTX3c has both consecutively with one amino acid substitution.[6]

Function

DTX3 functions as an E3 ubiquitin ligase.[7] Most but not all studies have found it to have a tumor-suppressing effect on human cancer: exceptions may be due to the failure to distinguish between different isoforms.[6]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000178498 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040415 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: Deltex E3 ubiquitin ligase 3". Retrieved 2016-09-26.
  6. 1 2 3 Scalia, Pierluigi; Williams, Stephen J.; Suma, Antonio; Carnevale, Vincenzo (2023-06-21). "The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer". Cells. 12 (13): 1680. doi:10.3390/cells12131680. ISSN 2073-4409. PMC 10340142. PMID 37443713.
  7. ↑ Takeyama, Kunihiko; Aguiar, Ricardo C. T.; Gu, Liqun; He, Chunyan; Freeman, Gordon J.; Kutok, Jeffery L.; Aster, Jon C.; Shipp, Margaret A. (2003-06-13). "The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity". The Journal of Biological Chemistry. 278 (24): 21930–21937. doi:10.1074/jbc.M301157200. ISSN 0021-9258. PMID 12670957.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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