This is a disambiguation page. Annihilation could refer to:
- Annihilation (comics), a 2006 Marvel Comics event featuring several cosmic characters
- Annihilation (Forgotten Realms novel), a 2004 novel by Philip Athans set in the Forgotten Realms universe
- Annihilation (VanderMeer novel), a 2014 novel by Jeff VanderMeer and the first entry in the Southern Reach Trilogy
- Annihilation (film), a 2018 film based on the VanderMeer novel
- Annihilation, a map pack for Call of Duty: Black Ops
- Mortal Kombat: Annihilation, the sequel to Mortal Kombat
- Total Annihilation, a 1997 Real Time Strategy game created by Chris Taylor and Cavedog Entertainment
- Total Annihilation Kingdoms, the follow-up to Total Annihilation
- Zero K, formerly known as "Complete Annihilation", a fork of "Balanced Annihilation" which itself was a fork of "Absolute Annihilation" which was a mod of Total Annihilation
You might also be looking for:
- Apocalypse How: A trope about the annihilation of societies, worlds and more
- Sphere of Destruction: A trope about a more localized kind of annihilation
- Family Annihilator, an alternate name for the trope Pater Familicide
- Guilt-Free Extermination War
- Kill All Humans
- Earthshattering Kaboom
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